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MOF-based nanoplatforms can also modulate anti-tumor immunity by influencing MDSCs in addition to nanocapsules, such as the (M+H)@ZIF/HA nanoparticles formed by the zeolite imidazolate framework-8 (ZIF-8) of the hyaluronic acid-modified mitoxantrone (MIT) and the DNA demethylating agent hydralazine (HYD) with pH response can convert cold tumors into antigen repertoire, stimulate robust immune responses and can effectively block MDSC-mediated T cell paralysis, triggering a strong cytotoxic T cell response to eliminate tumors (122)

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doi: 10.1016/j.ejim.2020.04.037 205 VioliF.OlivaA.CangemiR.CeccarelliG.PignatelliP.CarnevaleR.et al